Betting Odds and Predictions for the 2025 March Madness Sweet 16

Maryland Terrapins vs. Florida Gators:Florida -6 (-115)

In the Round of 32, the Florida Gators had to rely on all their resources against the UConn Huskies, narrowly defeating them 77-75 and stopping their bid for a three-peat.

Walter Clayton Jr. has been performing exceptionally well in this tournament and maintained his strong form against UConn, scoring 23 points after a similar performance against Norfolk State in the first round. Although the game against UConn was tight, the Gators appear to be a favorable matchup against Maryland.

The fourth-seeded Terrapins faced a challenging game in the Round of 32 as well, clinching the win against the Colorado State Rams with a buzzer-beater that ended the game at 72-71. This was the first buzzer-beater of the tournament, excluding the First Four matchups.

To compete successfully against the Gators, Maryland needs to elevate their game significantly.

This is the essence of March Madness 🔥 pic.twitter.com/50VFJdAASr

— The Sports Geek (@TheSports_Geek) March 24, 2025

With Clayton Jr. in top form, betting against the leading seed seems unwise. Serving as the leader of the team that boasts the third-highest points-per-game average in the tournament, Clayton Jr. is expected to perform well in crucial moments. Florida has been scoring an impressive 85.7 points per game as they enter the Sweet Sixteen. NCAA While Clayton Jr. is likely to have a standout performance, the real advantage may come from Florida's frontcourt. Look for players like Alex Condon and Thomas Haugh to play pivotal roles defensively against the Terrapins’ forwards. After overcoming their tough game against UConn, Florida appears poised for a strong showing.

I anticipate that Maryland will keep the game competitive in the first half, but Florida is likely to secure a victory by a margin of eight points. With that in mind, consider betting on Florida -6 for your Sweet 16 picks in 2025!

Michigan Wolverines vs. Auburn Tigers:

Just two rounds ago, the Michigan Wolverines were seen as a potential upset target against UC San Diego, but now they find themselves in the Sweet 16, just a win away from reaching the Elite 8! It took a fierce battle, but Michigan prevailed over UC San Diego with a 68-65 victory.Michigan +8 (-115)

While initially considered underdogs versus Texas A&M, Michigan demonstrated their strength by defeating the Aggies comfortably. Their performance against UC San Diego was markedly better in the Round of 32, as Dusty May’s team triumphed over Texas A&M with a decisive 91-79 score. When Michigan's players are confident, they can compete effectively against any team across the nation.

The Wolverines have shown inconsistency throughout the season, but hot streaks have also defined their journey. The hard-fought win against Texas A&M, a strong contender, should give them the momentum needed. Michigan excelled defensively in their recent Big Ten Tournament victory over Wisconsin, finishing 59-53.

As the number one overall seed, Auburn represents a significant challenge for Michigan. The Wolverines will likely rely on the strength of Daniel Wolf and Vladislav Goldin to hold their ground against Auburn's formidable squad.

Vladislav Goldin earned All-Big Ten honors, being recognized by the media and coaches for his impressive performance, adding second-team accolades from the Associated Press.

The Tigers have shown vulnerabilities in their defense this season, ranking 81st in the NCAA with an average of 69.4 points allowed per game. Michigan should be able to leverage Wolf and Goldin effectively to maintain proximity in the scoring.

Release: https://t.co/CD19UuRjfV #GoBlue pic.twitter.com/w8KEqGgbva

Although Auburn ranks seventh nationally with 83.8 points per game, Michigan has also proven to be capable with an average of 78.3 points this season. March 11, 2025

This contest could be closely contested until the end, making it sensible to take the points. In summary, as one of our top Sweet Sixteen picks for 2025 with a +8 line, the Wolverines deserve consideration against Auburn!

Purdue Boilermakers vs. Houston Cougars:

In this clash of the Big Ten and the top-seeded team, the Purdue Boilermakers aim to defeat the Houston Cougars. Although Purdue lacks the same depth of talent as last year's squad that reached the national championship game, they are currently being underestimated.Purdue +8 (-115)

Purdue put an end to McNeese State's fairy-tale run with a solid 76-62 victory in the Round of 32. The underdog entered the game with heightened confidence after eliminating Clemson but fell short against a stronger Purdue team.

Big Wins.

👉 8 of Purdue's last 9 wins in @MarchMadnessMBB have been by double-digits. pic.twitter.com/5Z1fUzue7r

Despite concluding the season fourth in the Big Ten with a 24-11 record, Purdue appears to be hitting their peak at an opportune moment. They faced setback against Michigan in the Big Ten Tournament but secured commendable victories over teams like USC and UCLA recently. March 23, 2025

Facing off against a tough Houston defense presents challenges for Purdue’s offense. Nonetheless, they possess the necessary talent in both their backcourt and frontcourt to compete fiercely. Though Zach Edey is no longer with the team, Trey Kaufman-Renn has stepped up admirably.

Kaufman-Renn's performance against McNeese highlighted his skills:

Averaging 20.3 points per game with a remarkable shooting percentage of 59.9%, Kaufman-Renn is crucial for Purdue's success against the Cougars. If he can dominate the paint, it significantly increases Purdue's chances of winning. Additionally, guard Braden Smith plays an integral role in the backcourt.

Smith is contributing 8.5 assists per game and is an effective scorer, averaging 16 points per game. Together, Kaufman-Renn and Smith present the Boilermakers with enough offensive firepower to cover the spread.

— 22 PTS
— 15 REBS
— 3 ASTS
— 1 BLK
— 1 STL
— 7/12 FG
— 8/10 FT #NBADraft pic.twitter.com/bNDpszIxmq

— No Ceilings (@NoCeilingsNBA) March 22, 2025

Ultimately, considering Purdue +8 is one of our top predictions for the Sweet Sixteen in men’s March Madness!

Smith is second in the NCAA in 2024-25 Betting on the Sweet 16 offers plenty of lucrative opportunities for astute bettors! The potential is vast, with various markets available during this time of year.

Consequently, choosing a sportsbook that offers a wide range of men's Sweet 16 2025 odds is essential. Based on our extensive experience with March Madness betting, Bovada ranks among the best options for the NCAA Tournament. Beyond pre-game lines, bettors can also explore prop bets and live betting opportunities during the Sweet 16!